Biocatalysis in the preparation of the statin side chain

: Liljeblad Arto, Kallinen Annukka, Kanerva Liisa T

: 2013

: Advances in Organic Synthesis

: 4

: 3

: 4

: 195

: 236

: 42

: 978-1-60805-587-6

: 1574-0870

DOI: https://doi.org/10.2174/97816080546881130301

Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.