A2 Refereed review article in a scientific journal
Biocatalysis in the preparation of the statin side chain
Authors: Liljeblad Arto, Kallinen Annukka, Kanerva Liisa T
Publication year: 2013
Journal: Advances in Organic Synthesis
Book title : Advances in Organic Synthesis
Number in series: 4
Volume: 3
Issue: 4
First page : 195
Last page: 236
Number of pages: 42
ISBN: 978-1-60805-587-6
ISSN: 1574-0870
DOI: https://doi.org/10.2174/97816080546881130301(external)
Abstract
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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