A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Biocatalysis in the preparation of the statin side chain
Tekijät: Liljeblad Arto, Kallinen Annukka, Kanerva Liisa T
Julkaisuvuosi: 2013
Journal: Advances in Organic Synthesis
Kokoomateoksen nimi: Advances in Organic Synthesis
Numero sarjassa: 4
Vuosikerta: 3
Numero: 4
Aloitussivu: 195
Lopetussivu: 236
Sivujen määrä: 42
ISBN: 978-1-60805-587-6
ISSN: 1574-0870
DOI: https://doi.org/10.2174/97816080546881130301
Tiivistelmä
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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