Susceptibilities of different Actinobacillus actinomycetemcomitans strains to lactoperoxidase-iodide-hydrogen peroxide combination and different antibiotics

: Ihalin R, Pienihakkinen K, Lenander M, Tenovuo J, Jousimies-Somer H

Publisher: ELSEVIER SCIENCE BV

: 2003

: International Journal of Antimicrobial Agents

: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

: INT J ANTIMICROB AG

: 21

: 5

: 434

: 440

: 7

: 0924-8579

DOI: https://doi.org/10.1016/S0924-8579(03)00008-6(external)

: https://www.sciencedirect.com/science/article/pii/S0924857903000086?via=ihub(external)

Actinobacillus actinomycetemcomitans has an important aetiological role in localized juvenile periodontitis and in progressive periodontitis in adults. A. actinomycetemcomitans is found mainly in periodontal pockets but also in whole saliva, a potential transmission medium. It is sensitive to peroxidase-halide systems, but the differences between periodontitis associated clinical isolates and type strains are unclear. The sensitivities of these 2 strain groups to lactoperoxidase (LP)-iodide (I-)-hydrogen peroxide (H2O2) combinations were investigated, and the sensitivities were compared with the susceptibilities to four antibiotics. There was great variation between the sensitivities of different strains, but the 2 strain groups responded similarly. The LP (75 mug)-I- (100 nmol)-H2O2 (1000 nmol) combination produced a similar degree of inhibition as 2 mug ampicillin. The LP-I- system might be a potential antimicrobial agent against A. actinomycetemcomitans transmission via saliva. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.