A1 Refereed original research article in a scientific journal
Susceptibilities of different Actinobacillus actinomycetemcomitans strains to lactoperoxidase-iodide-hydrogen peroxide combination and different antibiotics
Authors: Ihalin R, Pienihakkinen K, Lenander M, Tenovuo J, Jousimies-Somer H
Publisher: ELSEVIER SCIENCE BV
Publication year: 2003
Journal: International Journal of Antimicrobial Agents
Journal name in source: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Journal acronym: INT J ANTIMICROB AG
Volume: 21
Issue: 5
First page : 434
Last page: 440
Number of pages: 7
ISSN: 0924-8579
DOI: https://doi.org/10.1016/S0924-8579(03)00008-6
Web address : https://www.sciencedirect.com/science/article/pii/S0924857903000086?via=ihub
Abstract
Actinobacillus actinomycetemcomitans has an important aetiological role in localized juvenile periodontitis and in progressive periodontitis in adults. A. actinomycetemcomitans is found mainly in periodontal pockets but also in whole saliva, a potential transmission medium. It is sensitive to peroxidase-halide systems, but the differences between periodontitis associated clinical isolates and type strains are unclear. The sensitivities of these 2 strain groups to lactoperoxidase (LP)-iodide (I-)-hydrogen peroxide (H2O2) combinations were investigated, and the sensitivities were compared with the susceptibilities to four antibiotics. There was great variation between the sensitivities of different strains, but the 2 strain groups responded similarly. The LP (75 mug)-I- (100 nmol)-H2O2 (1000 nmol) combination produced a similar degree of inhibition as 2 mug ampicillin. The LP-I- system might be a potential antimicrobial agent against A. actinomycetemcomitans transmission via saliva. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
Actinobacillus actinomycetemcomitans has an important aetiological role in localized juvenile periodontitis and in progressive periodontitis in adults. A. actinomycetemcomitans is found mainly in periodontal pockets but also in whole saliva, a potential transmission medium. It is sensitive to peroxidase-halide systems, but the differences between periodontitis associated clinical isolates and type strains are unclear. The sensitivities of these 2 strain groups to lactoperoxidase (LP)-iodide (I-)-hydrogen peroxide (H2O2) combinations were investigated, and the sensitivities were compared with the susceptibilities to four antibiotics. There was great variation between the sensitivities of different strains, but the 2 strain groups responded similarly. The LP (75 mug)-I- (100 nmol)-H2O2 (1000 nmol) combination produced a similar degree of inhibition as 2 mug ampicillin. The LP-I- system might be a potential antimicrobial agent against A. actinomycetemcomitans transmission via saliva. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
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