Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [F-18]EF5



: Eskola O, Gronroos TJ, Forsback S, Tuomela J, Komar G, Bergman J, Harkonen P, Haaparanta M, Minn H, Solin O

Publisher: SPRINGER

: 2012

: Molecular Imaging and Biology

: MOLECULAR IMAGING AND BIOLOGY

: MOL IMAGING BIOL

: 2

: 14

: 2

: 205

: 212

: 8

: 1536-1632

DOI: https://doi.org/10.1007/s11307-011-0484-4


[F-18]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [F-18]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [F-18]EF5. Extensive metabolism was seen in mouse.



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