A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [F-18]EF5
Tekijät: Eskola O, Gronroos TJ, Forsback S, Tuomela J, Komar G, Bergman J, Harkonen P, Haaparanta M, Minn H, Solin O
Kustantaja: SPRINGER
Julkaisuvuosi: 2012
Journal: Molecular Imaging and Biology
Tietokannassa oleva lehden nimi: MOLECULAR IMAGING AND BIOLOGY
Lehden akronyymi: MOL IMAGING BIOL
Numero sarjassa: 2
Vuosikerta: 14
Numero: 2
Aloitussivu: 205
Lopetussivu: 212
Sivujen määrä: 8
ISSN: 1536-1632
DOI: https://doi.org/10.1007/s11307-011-0484-4
Tiivistelmä
[F-18]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [F-18]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [F-18]EF5. Extensive metabolism was seen in mouse.
[F-18]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [F-18]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [F-18]EF5. Extensive metabolism was seen in mouse.
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