A1 Refereed original research article in a scientific journal
Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [F-18]EF5
Authors: Eskola O, Gronroos TJ, Forsback S, Tuomela J, Komar G, Bergman J, Harkonen P, Haaparanta M, Minn H, Solin O
Publisher: SPRINGER
Publication year: 2012
Journal:Molecular Imaging and Biology
Journal name in sourceMOLECULAR IMAGING AND BIOLOGY
Journal acronym: MOL IMAGING BIOL
Number in series: 2
Volume: 14
Issue: 2
First page : 205
Last page: 212
Number of pages: 8
ISSN: 1536-1632
DOI: https://doi.org/10.1007/s11307-011-0484-4
Abstract
[F-18]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [F-18]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [F-18]EF5. Extensive metabolism was seen in mouse.
[F-18]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [F-18]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [F-18]EF5. Extensive metabolism was seen in mouse.
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