Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity



: Agnieszka A. Kaczor, Kalevi Pihlaja, Jari Sinkkonen, Kirsti Wiinamäki, Christiane Kronbach, Klaus Unverferth, Tomasz Wróbel, Tomasz Stachal, Dariusz Matosiuk

Publisher: WALTER DE GRUYTER GMBH

: 2014

: Heterocyclic Communications

: HETEROCYCLIC COMMUNICATIONS

: HETEROCYCL COMMUN

: 20

: 2

: 103

: 109

: 7

: 0793-0283

DOI: https://doi.org/10.1515/hc-2014-0006


Indole and carbazole derivatives were designed as non- competitive antagonists of the GluK2 receptor. The synthesized compounds were found to interact with the transduction domain of the receptor. The binding pocket is situated within one receptor subunit.




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