A1 Refereed original research article in a scientific journal

Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity



Authors: Agnieszka A. Kaczor, Kalevi Pihlaja, Jari Sinkkonen, Kirsti Wiinamäki, Christiane Kronbach, Klaus Unverferth, Tomasz Wróbel, Tomasz Stachal, Dariusz Matosiuk

Publisher: WALTER DE GRUYTER GMBH

Publication year: 2014

Journal: Heterocyclic Communications

Journal name in source: HETEROCYCLIC COMMUNICATIONS

Journal acronym: HETEROCYCL COMMUN

Volume: 20

Issue: 2

First page : 103

Last page: 109

Number of pages: 7

ISSN: 0793-0283

DOI: https://doi.org/10.1515/hc-2014-0006


Abstract

Indole and carbazole derivatives were designed as non- competitive antagonists of the GluK2 receptor. The synthesized compounds were found to interact with the transduction domain of the receptor. The binding pocket is situated within one receptor subunit.




Last updated on 2024-26-11 at 20:52