Expression of insulin-receptor substrate-1 and-2 in ovaries from women with insulin resistance and from controls

: Wu XK, Sallinen K, Anttila L, Makinen M, Luo C, Pollanen P, Erkkola R

Publisher: ELSEVIER SCIENCE INC

: 2000

: Fertility and Sterility

: FERTILITY AND STERILITY

: FERTIL STERIL

: 74

: 3

: 564

: 572

: 9

: 0015-0282

DOI: https://doi.org/10.1016/S0015-0282(00)00688-9(external)

Conclusion(s): This study highlights a shift of the follicular insulin signal protein from IRS-1 to IRS-2 in insulin-resistant states and suggests an association between this change and ovarian abnormality in PCOS and gestational diabetes mellitus. (Fertil Steril(R) 2000;74:564-72. (C) 2000 by American Society for Reproductive Medicine.).

Biomedicine