A1 Refereed original research article in a scientific journal
Expression of insulin-receptor substrate-1 and-2 in ovaries from women with insulin resistance and from controls
Authors: Wu XK, Sallinen K, Anttila L, Makinen M, Luo C, Pollanen P, Erkkola R
Publisher: ELSEVIER SCIENCE INC
Publication year: 2000
Journal: Fertility and Sterility
Journal name in source: FERTILITY AND STERILITY
Journal acronym: FERTIL STERIL
Volume: 74
Issue: 3
First page : 564
Last page: 572
Number of pages: 9
ISSN: 0015-0282
DOI: https://doi.org/10.1016/S0015-0282(00)00688-9
Abstract
Conclusion(s): This study highlights a shift of the follicular insulin signal protein from IRS-1 to IRS-2 in insulin-resistant states and suggests an association between this change and ovarian abnormality in PCOS and gestational diabetes mellitus. (Fertil Steril(R) 2000;74:564-72. (C) 2000 by American Society for Reproductive Medicine.).
Conclusion(s): This study highlights a shift of the follicular insulin signal protein from IRS-1 to IRS-2 in insulin-resistant states and suggests an association between this change and ovarian abnormality in PCOS and gestational diabetes mellitus. (Fertil Steril(R) 2000;74:564-72. (C) 2000 by American Society for Reproductive Medicine.).
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