A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Expression of insulin-receptor substrate-1 and-2 in ovaries from women with insulin resistance and from controls
Tekijät: Wu XK, Sallinen K, Anttila L, Makinen M, Luo C, Pollanen P, Erkkola R
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2000
Journal: Fertility and Sterility
Tietokannassa oleva lehden nimi: FERTILITY AND STERILITY
Lehden akronyymi: FERTIL STERIL
Vuosikerta: 74
Numero: 3
Aloitussivu: 564
Lopetussivu: 572
Sivujen määrä: 9
ISSN: 0015-0282
DOI: https://doi.org/10.1016/S0015-0282(00)00688-9
Tiivistelmä
Conclusion(s): This study highlights a shift of the follicular insulin signal protein from IRS-1 to IRS-2 in insulin-resistant states and suggests an association between this change and ovarian abnormality in PCOS and gestational diabetes mellitus. (Fertil Steril(R) 2000;74:564-72. (C) 2000 by American Society for Reproductive Medicine.).
Conclusion(s): This study highlights a shift of the follicular insulin signal protein from IRS-1 to IRS-2 in insulin-resistant states and suggests an association between this change and ovarian abnormality in PCOS and gestational diabetes mellitus. (Fertil Steril(R) 2000;74:564-72. (C) 2000 by American Society for Reproductive Medicine.).