Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes - indication of an increased environmental pressure?

: Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J

Publisher: SPRINGER-VERLAG

: 2003

: Diabetologia

: DIABETOLOGIA

: 46

: 3

: 420

: 425

: 6

: 0012-186X

DOI: https://doi.org/10.1007/s00125-003-1045-4

Conclusion/interpretation. Our data suggest that the need for genetic susceptibility to develop Type I diabetes has decreased over time due to an increasing environmental pressure and this results in a higher disease progression rate especially in subjects with protective HLA genotypes.