A1 Refereed original research article in a scientific journal

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes - indication of an increased environmental pressure?



Authors: Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J

Publisher: SPRINGER-VERLAG

Publication year: 2003

Journal: Diabetologia

Journal name in source: DIABETOLOGIA

Journal acronym: DIABETOLOGIA

Volume: 46

Issue: 3

First page : 420

Last page: 425

Number of pages: 6

ISSN: 0012-186X

DOI: https://doi.org/10.1007/s00125-003-1045-4


Abstract
Conclusion/interpretation. Our data suggest that the need for genetic susceptibility to develop Type I diabetes has decreased over time due to an increasing environmental pressure and this results in a higher disease progression rate especially in subjects with protective HLA genotypes.



Last updated on 2024-26-11 at 20:30