A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes - indication of an increased environmental pressure?
Tekijät: Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J
Kustantaja: SPRINGER-VERLAG
Julkaisuvuosi: 2003
Journal: Diabetologia
Tietokannassa oleva lehden nimi: DIABETOLOGIA
Lehden akronyymi: DIABETOLOGIA
Vuosikerta: 46
Numero: 3
Aloitussivu: 420
Lopetussivu: 425
Sivujen määrä: 6
ISSN: 0012-186X
DOI: https://doi.org/10.1007/s00125-003-1045-4
Tiivistelmä
Conclusion/interpretation. Our data suggest that the need for genetic susceptibility to develop Type I diabetes has decreased over time due to an increasing environmental pressure and this results in a higher disease progression rate especially in subjects with protective HLA genotypes.
Conclusion/interpretation. Our data suggest that the need for genetic susceptibility to develop Type I diabetes has decreased over time due to an increasing environmental pressure and this results in a higher disease progression rate especially in subjects with protective HLA genotypes.
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