A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Universal platform for quantitative analysis of DNA transposition
Tekijät: Pajunen MI, Rasila TS, Happonen LJ, Lamberg A, Haapa-Paananen S, Kiljunen S, Savilahti H
Kustantaja: BIOMED CENTRAL LTD
Julkaisuvuosi: 2010
Journal: Mobile DNA
Tietokannassa oleva lehden nimi: MOBILE DNA
Lehden akronyymi: MOBILE DNA-UK
Numero sarjassa: 24
Vuosikerta: 1
Numero: 24
Sivujen määrä: 14
ISSN: 1759-8753
DOI: https://doi.org/10.1186/1759-8753-1-24
Verkko-osoite: http://www.mobilednajournal.com/content/1/1/24
Tiivistelmä
Conclusions: The established universal papillation assay platform should be widely applicable to a variety of mobile elements. It can be used for mechanistic studies to dissect transposition and provides a means to screen or scrutinise transposase mutants and genes encoding host factors. In succession, improved versions of transposition systems should yield better tools for molecular biology and offer versatile genome modification vehicles for many types of studies, including gene therapy and stem cell research.
Conclusions: The established universal papillation assay platform should be widely applicable to a variety of mobile elements. It can be used for mechanistic studies to dissect transposition and provides a means to screen or scrutinise transposase mutants and genes encoding host factors. In succession, improved versions of transposition systems should yield better tools for molecular biology and offer versatile genome modification vehicles for many types of studies, including gene therapy and stem cell research.
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