High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
: Silbernagel G, Chapman MJ, Genser B, Kleber ME, Fauler G, Scharnagl H, Grammer TB, Boehm BO, Makela KM, Kahonen M, Carmena R, Rietzschel ER, Bruckert E, Deanfield JE, Miettinen TA, Raitakari OT, Lehtimaki T, Marz W
Publisher: ELSEVIER SCIENCE INC
: 2013
: Journal of the American College of Cardiology
: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
: J AM COLL CARDIOL
: 4
: 62
: 4
: 291
: 299
: 9
: 0735-1097
DOI: https://doi.org/10.1016/j.jacc.2013.01.100
Conclusions High cholesterol absorption is associated with risk alleles in ABCG8 and ABO and with CVD. Harm caused by elevated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of ABCG8 and ABO variants with CVD. (C) 2013 by the American College of Cardiology Foundation