A1 Refereed original research article in a scientific journal

High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis




AuthorsSilbernagel G, Chapman MJ, Genser B, Kleber ME, Fauler G, Scharnagl H, Grammer TB, Boehm BO, Makela KM, Kahonen M, Carmena R, Rietzschel ER, Bruckert E, Deanfield JE, Miettinen TA, Raitakari OT, Lehtimaki T, Marz W

PublisherELSEVIER SCIENCE INC

Publication year2013

JournalJournal of the American College of Cardiology

Journal name in sourceJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Journal acronymJ AM COLL CARDIOL

Number in series4

Volume62

Issue4

First page 291

Last page299

Number of pages9

ISSN0735-1097

DOIhttps://doi.org/10.1016/j.jacc.2013.01.100


Abstract
Conclusions High cholesterol absorption is associated with risk alleles in ABCG8 and ABO and with CVD. Harm caused by elevated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of ABCG8 and ABO variants with CVD. (C) 2013 by the American College of Cardiology Foundation


Research Areas



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