Solid support synthesis of ester linked hydrophobic conjugates of oligonucleotides



: Guzaev A, Lonnberg H

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

: 1999

Tetrahedron

TETRAHEDRON

: TETRAHEDRON

: 55

: 30

: 9101

: 9116

: 16

: 0040-4020

DOI: https://doi.org/10.1016/S0040-4020(99)00501-3


Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.



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