A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Solid support synthesis of ester linked hydrophobic conjugates of oligonucleotides
Tekijät: Guzaev A, Lonnberg H
Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD
Julkaisuvuosi: 1999
Lehti:: Tetrahedron
Tietokannassa oleva lehden nimi: TETRAHEDRON
Lehden akronyymi: TETRAHEDRON
Vuosikerta: 55
Numero: 30
Aloitussivu: 9101
Lopetussivu: 9116
Sivujen määrä: 16
ISSN: 0040-4020
DOI: https://doi.org/10.1016/S0040-4020(99)00501-3
Tiivistelmä
Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
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