A1 Refereed original research article in a scientific journal
Solid support synthesis of ester linked hydrophobic conjugates of oligonucleotides
Authors: Guzaev A, Lonnberg H
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 1999
Journal:: Tetrahedron
Journal name in source: TETRAHEDRON
Journal acronym: TETRAHEDRON
Volume: 55
Issue: 30
First page : 9101
Last page: 9116
Number of pages: 16
ISSN: 0040-4020
DOI: https://doi.org/10.1016/S0040-4020(99)00501-3
Abstract
Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
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