A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages



: Guzaev A, Lonnberg H

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

: 1997

: Tetrahedron Letters

: TETRAHEDRON LETTERS

: TETRAHEDRON LETT

: 38

: 22

: 3989

: 3992

: 4

: 0040-4039

DOI: https://doi.org/10.1016/S0040-4039(97)00739-9


A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.



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