A1 Refereed original research article in a scientific journal
A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages
Authors: Guzaev A, Lonnberg H
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 1997
Journal:: Tetrahedron Letters
Journal name in source: TETRAHEDRON LETTERS
Journal acronym: TETRAHEDRON LETT
Volume: 38
Issue: 22
First page : 3989
Last page: 3992
Number of pages: 4
ISSN: 0040-4039
DOI: https://doi.org/10.1016/S0040-4039(97)00739-9
Abstract
A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.
A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.
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