A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages
Tekijät: Guzaev A, Lonnberg H
Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD
Julkaisuvuosi: 1997
Lehti:: Tetrahedron Letters
Tietokannassa oleva lehden nimi: TETRAHEDRON LETTERS
Lehden akronyymi: TETRAHEDRON LETT
Vuosikerta: 38
Numero: 22
Aloitussivu: 3989
Lopetussivu: 3992
Sivujen määrä: 4
ISSN: 0040-4039
DOI: https://doi.org/10.1016/S0040-4039(97)00739-9
Tiivistelmä
A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.
A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.
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