A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Insights into the Evaporation Kinetics of Indomethacin Solutions
Tekijät: Hellsten S, Han B, Makila E, Niemi H, Salonen J, Lehto VP, Stelzer T, Louhi-Kultanen M, Ulrich J
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2013
Journal: Chemical Engineering and Technology
Tietokannassa oleva lehden nimi: CHEMICAL ENGINEERING & TECHNOLOGY
Lehden akronyymi: CHEM ENG TECHNOL
Numero sarjassa: 8
Vuosikerta: 36
Numero: 8
Aloitussivu: 1300
Lopetussivu: 1306
Sivujen määrä: 7
ISSN: 0930-7516
DOI: https://doi.org/10.1002/ceat.201200718
Verkko-osoite: http://www.scopus.com/inward/record.url?eid=2-s2.0-84880957504∂nerID=40&md5=de73160d41717141d3eabc102b42d99c
Tiivistelmä
Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 degrees C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.
Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 degrees C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.
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