A1 Refereed original research article in a scientific journal
Insights into the Evaporation Kinetics of Indomethacin Solutions
Authors: Hellsten S, Han B, Makila E, Niemi H, Salonen J, Lehto VP, Stelzer T, Louhi-Kultanen M, Ulrich J
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2013
Journal: Chemical Engineering and Technology
Journal name in source: CHEMICAL ENGINEERING & TECHNOLOGY
Journal acronym: CHEM ENG TECHNOL
Number in series: 8
Volume: 36
Issue: 8
First page : 1300
Last page: 1306
Number of pages: 7
ISSN: 0930-7516
DOI: https://doi.org/10.1002/ceat.201200718
Web address : http://www.scopus.com/inward/record.url?eid=2-s2.0-84880957504∂nerID=40&md5=de73160d41717141d3eabc102b42d99c
Abstract
Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 degrees C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.
Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 degrees C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.
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