Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam



: Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT

Publisher: MOSBY, INC

: 2006

: Clinical Pharmacology and Therapeutics

: CLINICAL PHARMACOLOGY & THERAPEUTICS

: CLIN PHARMACOL THER

: 79

: 4

: 362

: 370

: 9

: 0009-9236

DOI: https://doi.org/10.1016/j.clpt.2005.12.305


Conclusion: When midazolam is given as small intravenous bolus doses, its effect is not increased to a clinically significant degree by voriconazole. The use of large midazolam doses increases the risk of clinically significant interactions also after its intravenous administration. The use of oral midazolam with voriconazole should be avoided, or substantially lower doses should be used.



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