A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam
Tekijät: Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT
Kustantaja: MOSBY, INC
Julkaisuvuosi: 2006
Journal: Clinical Pharmacology and Therapeutics
Tietokannassa oleva lehden nimi: CLINICAL PHARMACOLOGY & THERAPEUTICS
Lehden akronyymi: CLIN PHARMACOL THER
Vuosikerta: 79
Numero: 4
Aloitussivu: 362
Lopetussivu: 370
Sivujen määrä: 9
ISSN: 0009-9236
DOI: https://doi.org/10.1016/j.clpt.2005.12.305
Tiivistelmä
Conclusion: When midazolam is given as small intravenous bolus doses, its effect is not increased to a clinically significant degree by voriconazole. The use of large midazolam doses increases the risk of clinically significant interactions also after its intravenous administration. The use of oral midazolam with voriconazole should be avoided, or substantially lower doses should be used.
Conclusion: When midazolam is given as small intravenous bolus doses, its effect is not increased to a clinically significant degree by voriconazole. The use of large midazolam doses increases the risk of clinically significant interactions also after its intravenous administration. The use of oral midazolam with voriconazole should be avoided, or substantially lower doses should be used.
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