A1 Refereed original research article in a scientific journal
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam
Authors: Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT
Publisher: MOSBY, INC
Publication year: 2006
Journal: Clinical Pharmacology and Therapeutics
Journal name in source: CLINICAL PHARMACOLOGY & THERAPEUTICS
Journal acronym: CLIN PHARMACOL THER
Volume: 79
Issue: 4
First page : 362
Last page: 370
Number of pages: 9
ISSN: 0009-9236
DOI: https://doi.org/10.1016/j.clpt.2005.12.305
Abstract
Conclusion: When midazolam is given as small intravenous bolus doses, its effect is not increased to a clinically significant degree by voriconazole. The use of large midazolam doses increases the risk of clinically significant interactions also after its intravenous administration. The use of oral midazolam with voriconazole should be avoided, or substantially lower doses should be used.
Conclusion: When midazolam is given as small intravenous bolus doses, its effect is not increased to a clinically significant degree by voriconazole. The use of large midazolam doses increases the risk of clinically significant interactions also after its intravenous administration. The use of oral midazolam with voriconazole should be avoided, or substantially lower doses should be used.
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