Solitary bronchial squamous cell papilloma – another human papillomavirus (HPV)-associated benign tumor
: systematic review and meta-analysis
: Syrjänen K, Syrjänen S
: 2013
: Contemporary Oncology
: 5
: 17
: 5
: 427
: 434
: 8
: 1428-2526
DOI: https://doi.org/10.5114/wo.2013.38565
: https://research.utu.fi/converis/portal/detail/Publication/2087720
Aim of the study: To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in bronchial squamous cell papillomas (SCP).
Material and methods: The literature was searched up to June 2012. The effect size was calculated as event rate (95% CI), with homogeneity testing using Cochran’s Q and I2 statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size, and potential publication bias was estimated using funnel plot symmetry.
Results: Fifteen studies were eligible, covering 89 bronchial SCPs from different geographic regions. Altogether, 38 (42.7%) cases tested HPV-positive; effect size 0.422 (95% CI: 0.311–0.542; fixed effects model), and 0.495 (95% CI: 0.316–0.675; random effects model). In meta-analysis stratified by i) HPV detection technique and ii) geographic study origin, the between-study heterogeneity was not significant for either; p = 0.348, and p = 0.792, respectively. In maximum likelihood meta-regression, HPV detection method (p = 0.150) and geographic origin of the study (p = 0.164) were not significant study-level covariates. Some evidence for publication bias was found only among in situ hybridization (ISH)-based studies and among studies from Europe, but with a negligible effect on summary effect size estimates. In sensitivity analysis, the meta-analytic results were robust to all one-by-one study removals.
Conclusions: In formal meta-regression, the variability in HPV detection rates reported in bronchial SCPs is not explained by the HPV detection method or geographic origin of the study.
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