A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Solitary bronchial squamous cell papilloma – another human papillomavirus (HPV)-associated benign tumor
Alaotsikko: systematic review and meta-analysis
Tekijät: Syrjänen K, Syrjänen S
Julkaisuvuosi: 2013
Journal: Contemporary Oncology
Numero sarjassa: 5
Vuosikerta: 17
Numero: 5
Aloitussivu: 427
Lopetussivu: 434
Sivujen määrä: 8
ISSN: 1428-2526
DOI: https://doi.org/10.5114/wo.2013.38565
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/2087720
Tiivistelmä
Aim of the study: To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in bronchial squamous cell papillomas (SCP).
Material and methods: The literature was searched up to June 2012. The effect size was calculated as event rate (95% CI), with homogeneity testing using Cochran’s Q and I2 statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size, and potential publication bias was estimated using funnel plot symmetry.
Results: Fifteen studies were eligible, covering 89 bronchial SCPs from different geographic regions. Altogether, 38 (42.7%) cases tested HPV-positive; effect size 0.422 (95% CI: 0.311–0.542; fixed effects model), and 0.495 (95% CI: 0.316–0.675; random effects model). In meta-analysis stratified by i) HPV detection technique and ii) geographic study origin, the between-study heterogeneity was not significant for either; p = 0.348, and p = 0.792, respectively. In maximum likelihood meta-regression, HPV detection method (p = 0.150) and geographic origin of the study (p = 0.164) were not significant study-level covariates. Some evidence for publication bias was found only among in situ hybridization (ISH)-based studies and among studies from Europe, but with a negligible effect on summary effect size estimates. In sensitivity analysis, the meta-analytic results were robust to all one-by-one study removals.
Conclusions: In formal meta-regression, the variability in HPV detection rates reported in bronchial SCPs is not explained by the HPV detection method or geographic origin of the study.
Aim of the study: To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in bronchial squamous cell papillomas (SCP).
Material and methods: The literature was searched up to June 2012. The effect size was calculated as event rate (95% CI), with homogeneity testing using Cochran’s Q and I2 statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size, and potential publication bias was estimated using funnel plot symmetry.
Results: Fifteen studies were eligible, covering 89 bronchial SCPs from different geographic regions. Altogether, 38 (42.7%) cases tested HPV-positive; effect size 0.422 (95% CI: 0.311–0.542; fixed effects model), and 0.495 (95% CI: 0.316–0.675; random effects model). In meta-analysis stratified by i) HPV detection technique and ii) geographic study origin, the between-study heterogeneity was not significant for either; p = 0.348, and p = 0.792, respectively. In maximum likelihood meta-regression, HPV detection method (p = 0.150) and geographic origin of the study (p = 0.164) were not significant study-level covariates. Some evidence for publication bias was found only among in situ hybridization (ISH)-based studies and among studies from Europe, but with a negligible effect on summary effect size estimates. In sensitivity analysis, the meta-analytic results were robust to all one-by-one study removals.
Conclusions: In formal meta-regression, the variability in HPV detection rates reported in bronchial SCPs is not explained by the HPV detection method or geographic origin of the study.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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