A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Evaluation of serum zonulin for use as an early predictor for gestational diabetes
Tekijät: Mokkala K, Tertti K, Rönnemaa T, Vahlberg T, Laitinen K
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2017
Journal: Nutrition and Diabetes
Tietokannassa oleva lehden nimi: NUTRITION & DIABETES
Lehden akronyymi: NUTR DIABETES
Artikkelin numero: ARTN e253
Vuosikerta: 7
Sivujen määrä: 3
ISSN: 2044-4052
DOI: https://doi.org/10.1038/nutd.2017.9
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/20516022
Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n = 88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml(-1) increase in zonulin: 1.08, 95% CI: 1.02-1.15; P = 0.009), diagnosed by a 2-h 75-g oral glucose tolerance test at late pregnancy. The optimal cutoff value was 43.3 ng ml(-1), with sensitivity of 88% (95% CI: 71-100%) and specificity of 47% (95% CI: 33-58%). The area under the ROC-curve was 0.67 (95% CI: 0.54-0.81). Our results show an association between increased earlypregnancy serum zonulin concentration and GDM, suggesting zonulin as a possible predictor for GDM.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
