A1 Refereed original research article in a scientific journal
Evaluation of serum zonulin for use as an early predictor for gestational diabetes
Authors: Mokkala K, Tertti K, Rönnemaa T, Vahlberg T, Laitinen K
Publisher: NATURE PUBLISHING GROUP
Publication year: 2017
Journal: Nutrition and Diabetes
Journal name in source: NUTRITION & DIABETES
Journal acronym: NUTR DIABETES
Article number: ARTN e253
Volume: 7
Number of pages: 3
ISSN: 2044-4052
DOI: https://doi.org/10.1038/nutd.2017.9(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/20516022(external)
Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n = 88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml(-1) increase in zonulin: 1.08, 95% CI: 1.02-1.15; P = 0.009), diagnosed by a 2-h 75-g oral glucose tolerance test at late pregnancy. The optimal cutoff value was 43.3 ng ml(-1), with sensitivity of 88% (95% CI: 71-100%) and specificity of 47% (95% CI: 33-58%). The area under the ROC-curve was 0.67 (95% CI: 0.54-0.81). Our results show an association between increased earlypregnancy serum zonulin concentration and GDM, suggesting zonulin as a possible predictor for GDM.
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