Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease



: Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M

Publisher: SPRINGER SPRINGER

: 2012

: European Journal of Nuclear Medicine and Molecular Imaging

: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

: EUR J NUCL MED MOL I

: 11

: 39

: 11

: 1784

: 1795

: 12

: 1619-7070

DOI: https://doi.org/10.1007/s00259-012-2178-9


Based on its pharmacokinetic profile, [F-18]flutemetamol showed potential as a PET tracer for preclinical imaging. It showed good brain uptake and was bound to A beta deposits in the brain of Tg2576 mice. However, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.



Last updated on 2024-26-11 at 20:52