A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease
Tekijät: Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M
Kustantaja: SPRINGER SPRINGER
Julkaisuvuosi: 2012
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Lehden akronyymi: EUR J NUCL MED MOL I
Numero sarjassa: 11
Vuosikerta: 39
Numero: 11
Aloitussivu: 1784
Lopetussivu: 1795
Sivujen määrä: 12
ISSN: 1619-7070
DOI: https://doi.org/10.1007/s00259-012-2178-9
Tiivistelmä
Based on its pharmacokinetic profile, [F-18]flutemetamol showed potential as a PET tracer for preclinical imaging. It showed good brain uptake and was bound to A beta deposits in the brain of Tg2576 mice. However, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.
Based on its pharmacokinetic profile, [F-18]flutemetamol showed potential as a PET tracer for preclinical imaging. It showed good brain uptake and was bound to A beta deposits in the brain of Tg2576 mice. However, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.
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