A1 Refereed original research article in a scientific journal

Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease



Authors: Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M

Publisher: SPRINGER SPRINGER

Publication year: 2012

Journal: European Journal of Nuclear Medicine and Molecular Imaging

Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Journal acronym: EUR J NUCL MED MOL I

Number in series: 11

Volume: 39

Issue: 11

First page : 1784

Last page: 1795

Number of pages: 12

ISSN: 1619-7070

DOI: https://doi.org/10.1007/s00259-012-2178-9


Abstract
Based on its pharmacokinetic profile, [F-18]flutemetamol showed potential as a PET tracer for preclinical imaging. It showed good brain uptake and was bound to A beta deposits in the brain of Tg2576 mice. However, its high lipophilicity might complicate the analysis of PET data, particularly in small-animal imaging.



Last updated on 2024-26-11 at 20:52