Epidemiology of CYP3A4-Mediated Clopidogrel Drug-Drug Interactions and Their Clinical Consequences



: Tirkkonen T, Heikkila P, Vahlberg T, Huupponen R, Laine K

Publisher: WILEY-BLACKWELL

: 2013

: Cardiovascular Therapeutics

: CARDIOVASCULAR THERAPEUTICS

: CARDIOVASC THER

: 6

: 31

: 6

: 344

: 351

: 8

: 1755-5914

DOI: https://doi.org/10.1111/1755-5922.12028


ConclusionsNo uniform untoward effect of concomitant CYP3A4 inhibitor use on the clinical efficacy of clopidogrel was found. In patients receiving concomitant atorvastatin and clopidogrel, the antithrombotic effect of clopidogrel was moderately attenuated, but the combination significantly reduced the overall mortality. CYP3A4 inhibitors and atorvastatin may reduce bleedings in clopidogrel users.



Last updated on 2024-26-11 at 11:51