A1 Refereed original research article in a scientific journal
Epidemiology of CYP3A4-Mediated Clopidogrel Drug-Drug Interactions and Their Clinical Consequences
Authors: Tirkkonen T, Heikkila P, Vahlberg T, Huupponen R, Laine K
Publisher: WILEY-BLACKWELL
Publication year: 2013
Journal: Cardiovascular Therapeutics
Journal name in source: CARDIOVASCULAR THERAPEUTICS
Journal acronym: CARDIOVASC THER
Number in series: 6
Volume: 31
Issue: 6
First page : 344
Last page: 351
Number of pages: 8
ISSN: 1755-5914
DOI: https://doi.org/10.1111/1755-5922.12028
Abstract
ConclusionsNo uniform untoward effect of concomitant CYP3A4 inhibitor use on the clinical efficacy of clopidogrel was found. In patients receiving concomitant atorvastatin and clopidogrel, the antithrombotic effect of clopidogrel was moderately attenuated, but the combination significantly reduced the overall mortality. CYP3A4 inhibitors and atorvastatin may reduce bleedings in clopidogrel users.
ConclusionsNo uniform untoward effect of concomitant CYP3A4 inhibitor use on the clinical efficacy of clopidogrel was found. In patients receiving concomitant atorvastatin and clopidogrel, the antithrombotic effect of clopidogrel was moderately attenuated, but the combination significantly reduced the overall mortality. CYP3A4 inhibitors and atorvastatin may reduce bleedings in clopidogrel users.
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