A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Epidemiology of CYP3A4-Mediated Clopidogrel Drug-Drug Interactions and Their Clinical Consequences
Tekijät: Tirkkonen T, Heikkila P, Vahlberg T, Huupponen R, Laine K
Kustantaja: WILEY-BLACKWELL
Julkaisuvuosi: 2013
Journal: Cardiovascular Therapeutics
Tietokannassa oleva lehden nimi: CARDIOVASCULAR THERAPEUTICS
Lehden akronyymi: CARDIOVASC THER
Numero sarjassa: 6
Vuosikerta: 31
Numero: 6
Aloitussivu: 344
Lopetussivu: 351
Sivujen määrä: 8
ISSN: 1755-5914
DOI: https://doi.org/10.1111/1755-5922.12028
Tiivistelmä
ConclusionsNo uniform untoward effect of concomitant CYP3A4 inhibitor use on the clinical efficacy of clopidogrel was found. In patients receiving concomitant atorvastatin and clopidogrel, the antithrombotic effect of clopidogrel was moderately attenuated, but the combination significantly reduced the overall mortality. CYP3A4 inhibitors and atorvastatin may reduce bleedings in clopidogrel users.
ConclusionsNo uniform untoward effect of concomitant CYP3A4 inhibitor use on the clinical efficacy of clopidogrel was found. In patients receiving concomitant atorvastatin and clopidogrel, the antithrombotic effect of clopidogrel was moderately attenuated, but the combination significantly reduced the overall mortality. CYP3A4 inhibitors and atorvastatin may reduce bleedings in clopidogrel users.
Turun yliopiston Tutkimustietojärjestelmän portaali