Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques



: Silvola JMU, Saraste A, Laitinen I, Savisto N, Laine VJO, Heinonen SE, Yla-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J

Publisher: ELSEVIER SCIENCE INC

: 2011

: JACC: Cardiovascular Imaging

: JACC-CARDIOVASCULAR IMAGING

: JACC-CARDIOVASC IMAG

: 12

: 4

: 12

: 1294

: 1301

: 8

: 1936-878X

DOI: https://doi.org/10.1016/j.jcmg.2011.07.009


CONCLUSIONS The 6-month-old LDLR(-/-)ApoB(100/100) and IGF-II/LDLR(-/-)ApoB(100/100) mice demonstrated highly inflamed, large, and extensive atherosclerotic plaques after 4 months of a high-fat diet, presenting a suitable model for studying the imaging of atherosclerotic plaque inflammation with (18)F-FDG. The presence of type 2 diabetes did not confound evaluation of plaque inflammation with (18)F-FDG. (J Am Coll Cardiol Img 2011;4:1294-301) (C) 2011 by the American College of Cardiology Foundation



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