A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques
Tekijät: Silvola JMU, Saraste A, Laitinen I, Savisto N, Laine VJO, Heinonen SE, Yla-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2011
Journal: JACC: Cardiovascular Imaging
Tietokannassa oleva lehden nimi: JACC-CARDIOVASCULAR IMAGING
Lehden akronyymi: JACC-CARDIOVASC IMAG
Numero sarjassa: 12
Vuosikerta: 4
Numero: 12
Aloitussivu: 1294
Lopetussivu: 1301
Sivujen määrä: 8
ISSN: 1936-878X
DOI: https://doi.org/10.1016/j.jcmg.2011.07.009
Tiivistelmä
CONCLUSIONS The 6-month-old LDLR(-/-)ApoB(100/100) and IGF-II/LDLR(-/-)ApoB(100/100) mice demonstrated highly inflamed, large, and extensive atherosclerotic plaques after 4 months of a high-fat diet, presenting a suitable model for studying the imaging of atherosclerotic plaque inflammation with (18)F-FDG. The presence of type 2 diabetes did not confound evaluation of plaque inflammation with (18)F-FDG. (J Am Coll Cardiol Img 2011;4:1294-301) (C) 2011 by the American College of Cardiology Foundation
CONCLUSIONS The 6-month-old LDLR(-/-)ApoB(100/100) and IGF-II/LDLR(-/-)ApoB(100/100) mice demonstrated highly inflamed, large, and extensive atherosclerotic plaques after 4 months of a high-fat diet, presenting a suitable model for studying the imaging of atherosclerotic plaque inflammation with (18)F-FDG. The presence of type 2 diabetes did not confound evaluation of plaque inflammation with (18)F-FDG. (J Am Coll Cardiol Img 2011;4:1294-301) (C) 2011 by the American College of Cardiology Foundation
Turun yliopiston Tutkimustietojärjestelmän portaali