A1 Refereed original research article in a scientific journal
Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques
Authors: Silvola JMU, Saraste A, Laitinen I, Savisto N, Laine VJO, Heinonen SE, Yla-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J
Publisher: ELSEVIER SCIENCE INC
Publication year: 2011
Journal: JACC: Cardiovascular Imaging
Journal name in source: JACC-CARDIOVASCULAR IMAGING
Journal acronym: JACC-CARDIOVASC IMAG
Number in series: 12
Volume: 4
Issue: 12
First page : 1294
Last page: 1301
Number of pages: 8
ISSN: 1936-878X
DOI: https://doi.org/10.1016/j.jcmg.2011.07.009
Abstract
CONCLUSIONS The 6-month-old LDLR(-/-)ApoB(100/100) and IGF-II/LDLR(-/-)ApoB(100/100) mice demonstrated highly inflamed, large, and extensive atherosclerotic plaques after 4 months of a high-fat diet, presenting a suitable model for studying the imaging of atherosclerotic plaque inflammation with (18)F-FDG. The presence of type 2 diabetes did not confound evaluation of plaque inflammation with (18)F-FDG. (J Am Coll Cardiol Img 2011;4:1294-301) (C) 2011 by the American College of Cardiology Foundation
CONCLUSIONS The 6-month-old LDLR(-/-)ApoB(100/100) and IGF-II/LDLR(-/-)ApoB(100/100) mice demonstrated highly inflamed, large, and extensive atherosclerotic plaques after 4 months of a high-fat diet, presenting a suitable model for studying the imaging of atherosclerotic plaque inflammation with (18)F-FDG. The presence of type 2 diabetes did not confound evaluation of plaque inflammation with (18)F-FDG. (J Am Coll Cardiol Img 2011;4:1294-301) (C) 2011 by the American College of Cardiology Foundation
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