Type 1 diabetes is insulin-2221 MspI and CTLA-4+49 A/G polymorphism dependent



: Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R

Publisher: BLACKWELL PUBLISHING LTD

: 2004

: European Journal of Clinical Investigation

: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

: EUR J CLIN INVEST

: 34

: 8

: 543

: 548

: 6

: 0014-2972

DOI: https://doi.org/10.1111/j.1365-2362.2004.01385.x


Conclusions There exists a significant association between the C-allele of -2221 MspI in the insulin gene and type 1 diabetes. The CTLA-4 G-allele is also positively correlated with type 1 diabetes. According to the regression model the investigated gene polymorphisms are independent risk factors for development of type 1 diabetes in the Estonian population. We propose that -2221 MspI is a good marker for evaluation of risk of insulin gene haplotype in type 1 diabetes patients.



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