A1 Refereed original research article in a scientific journal
Type 1 diabetes is insulin-2221 MspI and CTLA-4+49 A/G polymorphism dependent
Authors: Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
Publisher: BLACKWELL PUBLISHING LTD
Publication year: 2004
Journal: European Journal of Clinical Investigation
Journal name in source: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Journal acronym: EUR J CLIN INVEST
Volume: 34
Issue: 8
First page : 543
Last page: 548
Number of pages: 6
ISSN: 0014-2972
DOI: https://doi.org/10.1111/j.1365-2362.2004.01385.x
Abstract
Conclusions There exists a significant association between the C-allele of -2221 MspI in the insulin gene and type 1 diabetes. The CTLA-4 G-allele is also positively correlated with type 1 diabetes. According to the regression model the investigated gene polymorphisms are independent risk factors for development of type 1 diabetes in the Estonian population. We propose that -2221 MspI is a good marker for evaluation of risk of insulin gene haplotype in type 1 diabetes patients.
Conclusions There exists a significant association between the C-allele of -2221 MspI in the insulin gene and type 1 diabetes. The CTLA-4 G-allele is also positively correlated with type 1 diabetes. According to the regression model the investigated gene polymorphisms are independent risk factors for development of type 1 diabetes in the Estonian population. We propose that -2221 MspI is a good marker for evaluation of risk of insulin gene haplotype in type 1 diabetes patients.
UTU Research Portal