A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Type 1 diabetes is insulin-2221 MspI and CTLA-4+49 A/G polymorphism dependent
Tekijät: Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
Kustantaja: BLACKWELL PUBLISHING LTD
Julkaisuvuosi: 2004
Journal: European Journal of Clinical Investigation
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Lehden akronyymi: EUR J CLIN INVEST
Vuosikerta: 34
Numero: 8
Aloitussivu: 543
Lopetussivu: 548
Sivujen määrä: 6
ISSN: 0014-2972
DOI: https://doi.org/10.1111/j.1365-2362.2004.01385.x
Tiivistelmä
Conclusions There exists a significant association between the C-allele of -2221 MspI in the insulin gene and type 1 diabetes. The CTLA-4 G-allele is also positively correlated with type 1 diabetes. According to the regression model the investigated gene polymorphisms are independent risk factors for development of type 1 diabetes in the Estonian population. We propose that -2221 MspI is a good marker for evaluation of risk of insulin gene haplotype in type 1 diabetes patients.
Conclusions There exists a significant association between the C-allele of -2221 MspI in the insulin gene and type 1 diabetes. The CTLA-4 G-allele is also positively correlated with type 1 diabetes. According to the regression model the investigated gene polymorphisms are independent risk factors for development of type 1 diabetes in the Estonian population. We propose that -2221 MspI is a good marker for evaluation of risk of insulin gene haplotype in type 1 diabetes patients.
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