Nuclear Lamins



: Dechat T, Adam SA, Taimen P, Shimi T, Goldman RD

Publisher: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT

: 2010

: Cold Spring Harbor Perspectives in Biology

: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

: CSH PERSPECT BIOL

: ARTN a000547

: 11

: 2

: 11

: 22

: 1943-0264

DOI: https://doi.org/10.1101/cshperspect.a000547


The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.



Last updated on 2024-26-11 at 14:38