A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Nuclear Lamins
Tekijät: Dechat T, Adam SA, Taimen P, Shimi T, Goldman RD
Kustantaja: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Julkaisuvuosi: 2010
Journal: Cold Spring Harbor Perspectives in Biology
Tietokannassa oleva lehden nimi: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Lehden akronyymi: CSH PERSPECT BIOL
Artikkelin numero: ARTN a000547
Numero sarjassa: 11
Vuosikerta: 2
Numero: 11
Sivujen määrä: 22
ISSN: 1943-0264
DOI: https://doi.org/10.1101/cshperspect.a000547
Tiivistelmä
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.
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