A2 Refereed review article in a scientific journal
Nuclear Lamins
Authors: Dechat T, Adam SA, Taimen P, Shimi T, Goldman RD
Publisher: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Publication year: 2010
Journal: Cold Spring Harbor Perspectives in Biology
Journal name in source: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Journal acronym: CSH PERSPECT BIOL
Article number: ARTN a000547
Number in series: 11
Volume: 2
Issue: 11
Number of pages: 22
ISSN: 1943-0264
DOI: https://doi.org/10.1101/cshperspect.a000547(external)
Abstract
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.