A2 Refereed review article in a scientific journal

Nuclear Lamins




AuthorsDechat T, Adam SA, Taimen P, Shimi T, Goldman RD

PublisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT

Publication year2010

JournalCold Spring Harbor Perspectives in Biology

Journal name in sourceCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Journal acronymCSH PERSPECT BIOL

Article numberARTN a000547

Number in series11

Volume2

Issue11

Number of pages22

ISSN1943-0264

DOIhttps://doi.org/10.1101/cshperspect.a000547(external)


Abstract
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.



Last updated on 2024-26-11 at 14:38