Cleavage and isomerisation of UpU promoted by dinuclear metal ion complexes



: Linjalahti H, Feng G, Mareque-Rivas JC, Mikkola S, Williams NH

: 2008

: CHEMISTRY OF NUCLEIC ACID COMPONENTS

: COLL SYMPOS SERIES

: 10

: 404

: 406

: 3

: 978-80-86241-29-6


Reactions of UpU with dinuclear metal ion complexes have been studied. The complexes did not only efficiently promote the cleavage of the phosphodiester bond but, remarkably, catalysed the isomerisation of the diester. This implies that the reaction involves the formation of a sufficiently long-lived phosphorane intermediate which can pseudorotate.



Last updated on 2024-26-11 at 22:32